Oseltamavir

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General

  • Type: Antiviral - neuraminidase inhibitor
  • Dosage Forms: capsule (30, 45, 75mg), powder for PO susp (6mg/mL)
  • Common Trade Names: Tamiflu

Adult Dosing

Influenza

75mg PO BID x5d

Pediatric Dosing

5 day course

  • 1-8 months: 3mg/kg PO BID
  • 9-23 months: 3.5mg/kg PO BID
  • 2-12 years:
    • <15kg: 30mg PO BID
    • 16-23kg: 45mg PO BID
    • 24-40kg: 60mg PO BID
    • >40kg: 75mg PO BID

Special Populations

  • Pregnancy Rating: Category C
  • Lactation: Unknown; caution required
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Rare <1%

Arrhythmia, delirium, hemorrhagic colitis, hepatitis, seizure, TEN, SJS, angioedema, unstable angina, pseudomembranous colitis

Common

Abdominal pain, insomnia, nausea, vomitting, vertigo, epistaxis, ear complaints, conjunctivitis.

Pharmacology

  • Half-life: 1-3 hrs (oseltamivir); 6-10hrs oseltamivir carboxylate)
  • Metabolism: hepatic
  • Excretion: urine/stool
  • Mechanism of Action: competitive inhibition of influenza virus neuraminidase enzyme, effectively halting viral release from infected cells and passing through mucus membranes.

See Also

References