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Oseltamavir
From WikEM
Contents
General
- Type: Antiviral - neuraminidase inhibitor
- Dosage Forms: capsule (30, 45, 75mg), powder for PO susp (6mg/mL)
- Common Trade Names: Tamiflu
Adult Dosing
Influenza
75mg PO BID x5d
Pediatric Dosing
5 day course
- 1-8 months: 3mg/kg PO BID
- 9-23 months: 3.5mg/kg PO BID
- 2-12 years:
- <15kg: 30mg PO BID
- 16-23kg: 45mg PO BID
- 24-40kg: 60mg PO BID
- >40kg: 75mg PO BID
Special Populations
- Pregnancy Rating: Category C
- Lactation: Unknown; caution required
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Rare <1%
Arrhythmia, delirium, hemorrhagic colitis, hepatitis, seizure, TEN, SJS, angioedema, unstable angina, pseudomembranous colitis
Common
Abdominal pain, insomnia, nausea, vomitting, vertigo, epistaxis, ear complaints, conjunctivitis.
Pharmacology
- Half-life: 1-3 hrs (oseltamivir); 6-10hrs oseltamivir carboxylate)
- Metabolism: hepatic
- Excretion: urine/stool
- Mechanism of Action: competitive inhibition of influenza virus neuraminidase enzyme, effectively halting viral release from infected cells and passing through mucus membranes.
See Also
References
Authors
Ross Donaldson, Dac Teoli, Neil Young, Daniel Ostermayer, Michael Holtz
