A myxoma: a gelatinous tumor attached by a narrow pedicle to the atrial septum. The myxoma has an irregular surface and nearly fills the left atrium.
  • Most common primary cardiac neoplasm
  • ~80% of myxomas originate in the left atrium, with the remainder in the right atrium[1]

Clinical Features

  • Cardiovascular symptoms mimicking mitral valve obstruction (e.g., left atrial hypertrophy)
  • Increased risk of systemic embolization
  • Constitutional symptoms (e.g., fever, weight loss)

Differential Diagnosis


(A) Cardiac MRI showing atrial myxoma during systole. (B) Cardiac MRI showing atrial myxoma during diastole. RA – right atrium; RV – right ventricle; LA – left atrium; LV – left ventricle; arrow – myxoma.
Left atrial myxomas. (a) Parasternal long-axis view showing wedging of the myxoma into the mitral valve; (b) same case (four chamber view); (c) three-dimensional transesophageal echocardiography visualization of a left atrium myxoma attached to the posterior wall of the left atrium proximal to the pulmonary vein; (d) transesophageal echocardiography four chamber view of a large left atrium myxoma obstructing the mitral valve.



  • Typical location of myxomas is amenable to visualization with TTE


  • Once presumptive diagnosis made, prompt resection is required due to elevated risk of embolization or cardiac complications[2]


See Also

External Links


  1. Kuon E, Kreplin M, Weiss W, Dahm JB. The challenge presented by right atrial myxoma. Herz. 2004 Nov;29(7):702-9. doi: 10.1007/s00059-004-2571-7. PMID: 15580325.
  2. Keeling IM, Oberwalder P, Anelli-Monti M, Schuchlenz H, Demel U, Tilz GP, Rehak P, Rigler B. Cardiac myxomas: 24 years of experience in 49 patients. Eur J Cardiothorac Surg. 2002 Dec;22(6):971-7. doi: 10.1016/s1010-7940(02)00592-4. PMID: 12467822.