Hodgkin's lymphoma

Background

  • Spreads from source lymph node to adjacent nodes
  • About half of cases related to Epstein-Barr virus[1]
    • HIV is also a risk factor
  • More common in males
  • Bimodal distribution: young adulthood and older aged
  • Most common malignancy in ages 15-19 years
  • Survival >90% in low-risk patients

Clinical Features

  • Painless, firm, lymph node (usually cervical or supraclavicular)
  • "B" symptoms: fever, night sweats, weight loss

Differential Diagnosis

Cervical Lymphadenopathy

Acute Leukemia/Lymphoma

Evaluation

  • CXR
  • CT neck/chest/abdomen/pelvis
  • Lymph node biopsy
    • Reed-Sternberg cells next to normal lymphocytes

Management

See Also

References

  1. World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 2.4