D-dimer

Differential Diagnosis

Evaluation

  • Traditional cutoff value = 500
  • Age-adjusted (for over 50 years old) = age x 10
    • Maintains high sensitivity while increasing specificity[1]
  • YEARS[2] and PEGeD[3] adjust cut off base on clinical probability still being studied.

See Also

External Links

References

  1. Sharp AL, et al. An Age-Adjusted D-dimer Threshold for Emergency Department Patients with Suspected Pulmonary Embolus: Accuracy and Clinical Implications. Feb 2016. Annals of EM. 67(2);249-257.
  2. MDCalc YEARS https://www.mdcalc.com/years-algorithm-pulmonary-embolism-pe
  3. Anand Swaminathan, "PEGeD Study – Is It Safe to Adjust the D-Dimer Threshold for Clinical Probability?", REBEL EM blog, December 16, 2019. Available at: https://rebelem.com/peged-study-is-it-safe-to-adjust-the-d-dimer-threshold-for-clinical-probability/