Hydrocortisone/neomycin/polymyxin

(Redirected from Cortisporin otic)

Administration

  • Type: topical antibiotic/steroid
  • Dosage Forms:
  • Routes of Administration: topical
  • Common Trade Names: Cortisporin otic

Adult Dosing

  • 4 drops in ear q6-8hr

Pediatric Dosing

  • 3 drops in ear q6-8hr

Special Populations

Pregnancy Rating

  • Category C

Lactation risk

  • Unknown whether drug is excreted in milk; use with caution

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • Cutaneous viral infection of the external auditory canal (e.g. patients with herpes simplex, vaccinia, and varicella infections)

Adverse Reactions

Serious

  • Neomycin sensitization with itching, reddening, edema, and failure to heal
  • Systemic absorption of topical corticosteroids--> HPA axis suppression --> adrenal crisis
  • Prolonged use of corticosteroids may lead to increase incidence of infection, masking of infection, limited response to vaccines
  • Prolonged use of corticosteroids associated with development of Kaposi sarcoma

Common

  • Itching
  • Redness
  • Rash
  • Swelling

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:

Mechanism of Action

  • Hydrocortisone: Suppresses inflammatory response
  • Polymyxin: disrupts bacterial cytoplasmic membrane permeability allowing leakage of intracellular contents--> bactericidal
  • Neomycin: Inhibits protein synthesis

Comments

See Also

References

Authors:

Claire