Clofazimine

Administration

  • Type: Antibiotic
  • Dosage Forms: CAP 50mg
  • Routes of Administration: Oral
  • Common Trade Names: Lamprene

Adult Dosing

Hansen's disease, multibacillary

  • 50mg PO qd x 12mo in combination with rifampin and dapsone
    • Give 300mg PO qmo x 12mo in addition to daily dose

Erythema nodosum leprosum

  • 100mg PO bid x12wk, then 100mg PO qd 12-24wk
    • Start 100mg PO tid x12wek

Pediatric Dosing

Hansen's disease, multibacillary

  • 10-14 yo: 50mg PO qod AND 150mg PO qmo x12mo in combination with rifampin and dapsone
  • >15 yo: 50mg PO qd AND 300mg PO qmo x 12mo in combination with rifampin and dapsone

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Caution advised
  • Renal dosing: not defined
  • Hepatic dosing: not defined

Contraindications

  • Allergy to class/drug
  • Caution:


Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 70 days
  • Metabolism: Unknown
  • Excretion: Feces primarily

Mechanism of Action

  • Bacteriostatic or bactericidal: Binds to mycobacterial DNA, inhibiting growth


Comments

See Also

References