Clofazimine
Contents
Administration
- Type: Antibiotic
- Dosage Forms: CAP 50mg
- Routes of Administration: Oral
- Common Trade Names: Lamprene
Adult Dosing
Hansen's disease, multibacillary
- 50mg PO qd x 12mo in combination with rifampin and dapsone
- Give 300mg PO qmo x 12mo in addition to daily dose
Erythema nodosum leprosum
- 100mg PO bid x12wk, then 100mg PO qd 12-24wk
- Start 100mg PO tid x12wek
Pediatric Dosing
Hansen's disease, multibacillary
- 10-14 yo: 50mg PO qod AND 150mg PO qmo x12mo in combination with rifampin and dapsone
- >15 yo: 50mg PO qd AND 300mg PO qmo x 12mo in combination with rifampin and dapsone
Special Populations
- Pregnancy Rating: C
- Lactation risk: Caution advised
- Renal dosing: not defined
- Hepatic dosing: not defined
Contraindications
- Allergy to class/drug
- Caution:
- Electrolyte abnormality
- Congenital long QT syndrome, QT prolongation or family history of long QT
- Torsades de pointes, ventricular arrhythmias
- Bradycardia
- Recent MI
- CHF
Adverse Reactions
Serious
- Severe abdominal symptoms
- Hepatitis, Jaundice
- Intestinal obstruction
- GI Bleeding
- Splenic infarction
- Thromboembolism
- QT Prolongation, Torsades de pointes
Common
- Skin discoloration
- Nausea/Vomiting, diarrhea, abdominal/epigastric pain
- Ichthyosis/xeroderma
- Pruritus/rash
- Discolored urine/feces/sputum/sweat
- Ocular pigmentation, ocular irritation
- Hyperglycemia
- ESR elevated
Pharmacology
- Half-life: 70 days
- Metabolism: Unknown
- Excretion: Feces primarily
Mechanism of Action
- Bacteriostatic or bactericidal: Binds to mycobacterial DNA, inhibiting growth