Clobetasol

(Redirected from Clobetasol propionate)

Administration

  • Type: Topical steroid
  • Dosage Forms: cream, emollient, foam, gel, lotion, ointment, spray, shampoo
  • Routes of Administration: topical
  • Common Trade Names: Olux, Temovate, Clobex, Cormax

Adult Dosing

  • Most indications: apply to affected area of skin BID, max 50g/week
  • Genital lichen sclerosus: apply to vulva once daily
  • Scalp psoriasis: apply shampoo to affected areas dry scalp once daily; leave in place 15 minutes before lathering and rinsing. Max 50ml/week x 2 weeks

Pediatric Dosing

Safety/efficacy not established in children <12yo

Special Populations

Contraindications

  • Allergy to class/drug
  • Primary scalp infection

Adverse Reactions

Serious

  • Secondary hypocortisolism (higher risk in pediatrics)
  • Intracranial hypertension

Common

  • Skin atrophy, asteatotic eczema
  • Skin irritation, burning, discomfort, dryness
  • Pruritus
  • Telangiectasia
  • Upper respiratory infection

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:

Mechanism of Action

  • High potency synthetic corticosteroid, anti-inflammatory

Comments

See Also

References

  • Bae YS, Van Voorhees AS, Hsu S, et al.; National Psoriasis Foundation. Review of treatment options for psoriasis in pregnant or lactating women: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol. 2012;67(3):459-477. doi: 10.1016/j.jaad.2011.07.039. [PubMed 22018758]
  • Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014;70(3):417.e1-10; quiz 427. doi: 10.1016/j.jaad.2013.09.009. [PubMed 24528912]
  • Carrillo Dde L. Vegetating darier's disease during pregnancy. Acta Derm Venereol. 2006;86(3):259-260. [PubMed 16710592]
  • Chi CC, Kirtschig G, Aberer W, et al. Updated evidence-based (S2e) European Dermatology Forum guideline on topical corticosteroids in pregnancy. J Eur Acad Dermatol Venereol. 2017;31(5):761-773. doi: 10.1111/jdv.14101. [PubMed 28233354]
  • Chi CC, Wang SH, Kirtschig G. Safety of Topical Corticosteroids in Pregnancy. JAMA Dermatol. 2016;152(8):934-935. doi: 10.1001/jamadermatol.2016.1009. [PubMed 27366995]
  • Clobex Lotion (clobetasol) [prescribing information]. Fort Worth, TX: Galderma Laboratories; July 2014.
  • Clobex shampoo (clobetasol) [prescribing information]. Fort Worth, TX: Galderma Laboratories; November 2012.
  • Clobex Shampoo (clobetasol) [product monograph]. Thornhill, ON: Galderma Canada INC; November 2017.
  • Clobex Spray (clobetasol) [product monograph]. Thornhill, ON: Galderma Canada INC; December 2018.
  • Clodan (clobetasol) [prescribing information]. Fairfield, NJ: Medimetriks Pharmaceuticals; January 2016.


Authors:

Claire