(Redirected from Carbamazepine Toxicity)
- Has anticholinergic, sodium-channel blockade, anti-NMDA and antiepileptic effects
- Therapeutic concentration: 4-12 mg/L
May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- Anticholinergic Toxicity
- Levels do not accurately correlate with clinical severity
- GI decontamination
- Dialysis for severe cases. Indications: 
- Intractable seizures or life threatening dysrhythmia (level 1D recommendation)
- Respiratory depression requiring mechanical ventilation or prolonged coma (level 2D suggestion)
- Significant toxicity or rising/persistent carbamazepine level despite activated charcoal and supportive care (level 2D suggestion)
- Consider discharge for patient with decreasing levels (measured few hrs apart) and is asymptomatic
- Novartis Pharmaceuticals USA. Prescribing information for Tegretol CR400(R) tablets www.pharma.us.novartis.com/product/pi/pdf/tegretol.pdf (Accessed on August 27, 2008).
- Ghannoum M, Yates C, Galvao TF et al. Extracorporeal treatment for carbamazepine poisoning: Systematic review and recommendations from the EXTRIP workgroup. Clin Tox 2016. 52(10):993-1004.