Benazepril

Administration

  • Type: ACE inhibitor
  • Dosage Forms:
  • Routes of Administration: PO
  • Common Trade Names: Lotensin

Adult Dosing

  • 2-80mg PO in one or two daily doses

Pediatric Dosing

  • >6yo: 0.2-0.6mg/kg daily, max 40mg/day

Special Populations

Pregnancy Rating

  • Category D (fetal risk demonstrated)

Lactation risk

  • Infant risk is minimal

Renal Dosing

  • Adult: GFR <30 or Cr >3: 5-40mg daily
  • Pediatric: not recommended if GFR <30

Hepatic Dosing

  • Adult: Not established
  • Pediatric: Not established

Contraindications

  • Allergy to class/drug
  • Angioedema history
  • Concomitant aliskiren use in diabetic patients
  • Concomitant or recent (<36h) neprilysin inhibitors (e.g. sacubitril)

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Adult: 10-11h, pediatric: ~5h
  • Metabolism: hepatic
  • Excretion: renal, biliary

Mechanism of Action

  • ACE inhibitor: inhibits conversion of angiotensin I to angiotensin II, which decreases vasopressor activity and aldosterone activity

Comments

See Also

References

Authors:

Claire