Santa Monica:Antibiotics in Sepsis

Unknown Source

  • Primary Therapy
  • If allergy or prior exposure
    • aztreonam 2g IV q8h OR levofloxacin 750mg IV q24h
    • +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
    • +/- gentamicin 7mg/kg/dose IV q24h
    • +/- fluconazole 400mg IV q24h

Pneumonia (Community)

  • Comm. Acquired
  • If allergy or prior exposure
    • Levofloxacin 750mg IV q24h AND Aztreonam 2g IV q8h

Pneumonia (Healthcare Assoc/Pseudomonas Risk)

  • Primary therapy
  • If allergy or prior exposure
    • levofloxacin 750mg IV q24h
    • +/- azithromycin 500mg IV q24h
    • +/- gentamicin extended interval 7mg/kg/dose IV q24h

Abdominal/Pelvic

Urosepsis

Heme/Onch

  • Primary therapy
    • meropenem 1g IV q8h
    • +/- vancomycin 15mg/kg/dose IV q12h [Maximum dose of 1500mg]
  • If allergy or prior exposure

See Also

References

Santa-Monica UCLA 5/12

Authors:

Ross Donaldson