Yohimbine toxicity: Difference between revisions
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==Background== | ==Background== | ||
Indole alkylamine from West African Yohimbine tree (''Corynanthe yohimbe'') | [[File:Pau de cabinda.jpg|thumb|Corynanthe johimbe, common name yohimbe]] | ||
α2-adrenergic antagonist with cholinergic activity< | [[File:Yohimbe.jpg|thumb|Yohimbe bark]] | ||
Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent. | *Indole alkylamine from West African Yohimbine tree (''Corynanthe yohimbe'') | ||
Can be obtained via prescription. | **Is a plant species in the family Rubiaceae native to western and central Africa (Nigeria, Cabinda, Cameroon, Congo-Brazzaville, Gabon, Equatorial Guinea) | ||
**Extracts from yohimbe have been used in traditional medicine in West Africa as an aphrodisiac and have been marketed in developed countries as dietary supplements. | |||
*α2-adrenergic antagonist with cholinergic activity<ref>Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.</ref> | |||
*Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent. | |||
*Can be obtained via prescription. | |||
==Clinical Features== | ==Clinical Features<ref>Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.</ref>== | ||
*Tachycardia | *[[Tachycardia]] | ||
*Hypertension | *[[Hypertension]] | ||
*Mydriasis | *[[Mydriasis]] | ||
*Nausea, vomiting, salivation | *[[Nausea]], [[vomiting]], salivation | ||
*Anxiety | *[[Anxiety]] | ||
*Large ingestions may cause mania, bronchospasm, lupus-like syndrome | *Large ingestions may cause mania, bronchospasm, lupus-like syndrome | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
==Evaluation== | |||
==Management== | ==Management== | ||
'' | ''Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension'' | ||
*Symptomatic patients: | |||
**Benzodiazepines for agitation/anxiety/sympathomimetic effects | |||
Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension | |||
==Disposition== | |||
==See Also== | ==See Also== | ||
*[[Alpha blockers]] | |||
==External Links== | ==External Links== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Toxicology]] | |||
Latest revision as of 19:28, 31 August 2022
Background
- Indole alkylamine from West African Yohimbine tree (Corynanthe yohimbe)
- Is a plant species in the family Rubiaceae native to western and central Africa (Nigeria, Cabinda, Cameroon, Congo-Brazzaville, Gabon, Equatorial Guinea)
- Extracts from yohimbe have been used in traditional medicine in West Africa as an aphrodisiac and have been marketed in developed countries as dietary supplements.
- α2-adrenergic antagonist with cholinergic activity[1]
- Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent.
- Can be obtained via prescription.
Clinical Features[2]
- Tachycardia
- Hypertension
- Mydriasis
- Nausea, vomiting, salivation
- Anxiety
- Large ingestions may cause mania, bronchospasm, lupus-like syndrome
Differential Diagnosis
Evaluation
Management
Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension
- Symptomatic patients:
- Benzodiazepines for agitation/anxiety/sympathomimetic effects
Disposition
See Also
External Links
References
- ↑ Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.
- ↑ Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.