Yohimbine toxicity: Difference between revisions
No edit summary |
|||
| Line 1: | Line 1: | ||
==Background== | ==Background== | ||
Indole alkylamine from West African Yohimbine tree (''Corynanthe yohimbe'') | *Indole alkylamine from West African Yohimbine tree (''Corynanthe yohimbe'') | ||
α2-adrenergic antagonist with cholinergic activity< | *α2-adrenergic antagonist with cholinergic activity<ref>Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.</ref> | ||
Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent. | *Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent. | ||
Can be obtained via prescription. | *Can be obtained via prescription. | ||
==Clinical Features== | ==Clinical Features<ref>Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.</ref>== | ||
*Tachycardia | *[[Tachycardia]] | ||
*Hypertension | *[[Hypertension]] | ||
*Mydriasis | *[[Mydriasis]] | ||
*Nausea, vomiting, salivation | *[[Nausea]], [[vomiting]], salivation | ||
*Anxiety | *[[Anxiety]] | ||
*Large ingestions may cause mania, bronchospasm, lupus-like syndrome | *Large ingestions may cause mania, bronchospasm, lupus-like syndrome | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
==Evaluation== | |||
==Management== | ==Management== | ||
'' | ''Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension'' | ||
*Symptomatic patients: | |||
**Benzodiazepines for agitation/anxiety/sympathomimetic effects | |||
Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension | |||
==Disposition | |||
==See Also== | ==See Also== | ||
| Line 27: | Line 28: | ||
==External Links== | ==External Links== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 23:07, 20 October 2018
Background
- Indole alkylamine from West African Yohimbine tree (Corynanthe yohimbe)
- α2-adrenergic antagonist with cholinergic activity[1]
- Commonly used for treating erectile dysfunction. Also, for other uses (eg, postural hypotension); marketed as athletic performance enhancers, dieting agent.
- Can be obtained via prescription.
Clinical Features[2]
- Tachycardia
- Hypertension
- Mydriasis
- Nausea, vomiting, salivation
- Anxiety
- Large ingestions may cause mania, bronchospasm, lupus-like syndrome
Differential Diagnosis
Evaluation
Management
Avoid β-Adrenergic antagonists - may lead to unopposed α1-adrenergic activity → ↑ hypertension
- Symptomatic patients:
- Benzodiazepines for agitation/anxiety/sympathomimetic effects
==Disposition
See Also
External Links
References
- ↑ Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.
- ↑ Chu J. Genitourinary Principles. In: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. eds. Goldfrank's Toxicologic Emergencies, 10e New York, NY: McGraw-Hill; 2015.