Vitamin E deficiency

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Background

  • Most common causes:
    • Severe malabsorption (eg, cystic fibrosis)
    • Abetalipoproteinemia (genetic disorder)
    • Chronic cholestatic liver disease (e.g. biliary atresia)

Clinical Features

  • Areflexia
  • Gait disturbance
  • Decreased vibration and proprioception
  • Ophthalmoplegia

Differential Diagnosis

Evaluation

  • Plasma Vitamin E level <0.5 mg/dL

Management

  • Vitamin E repletion

Disposition

See Also

External Links

References

Authors:

Claire