Vaso-occlusive pain crisis: Difference between revisions
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**Assess for significant anemia | **Assess for significant anemia | ||
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**If | **If abdominal pain, may be cholecystitis, mesenteric ischemia, or perforation | ||
*Retic count (if aplastic crisis considered - rare in adults) | *Retic count (if aplastic crisis considered - rare in adults) | ||
**Should be >0.5% | **Should be >0.5% |
Revision as of 04:49, 15 July 2016
Background
Precipitating Factors
- For vaso-occlusion:
- Stress
- Cold weather
- Dehydration
- Hypoxia
- Infection
- Acidosis
- Alcohol intoxication
- Pregnancy
- Exertional stress
Clinical Features[1]
- Pain
- Most common manifestation of SCA (79-91% of ED visits)
- Lower back, long bones most commonly affected
- Because anemia can precipitate a crisis, must check for acute Hb drop
Differential Diagnosis
Sickle cell crisis
- Vaso-occlusive pain crisis
- Bony infarction
- Dactylitis
- Avascular necrosis of femoral head
- Acute chest syndrome
- Asthma
- Pulmonary hypertension
- Gallbladder disease
- Acute hepatic sequestration
- Infection
- Parvovirus B19
- Splenic sequestration
- CVA
- Cerebral aneurysm and ICH
- Priapism
- Papillary necrosis
Diagnosis
- CBC
- Assess for significant anemia
- Chemistry / LFT / lipase
- If abdominal pain, may be cholecystitis, mesenteric ischemia, or perforation
- Retic count (if aplastic crisis considered - rare in adults)
- Should be >0.5%
- CXR
- If cough, SOB, or febrile
- O2
- If hypoxic; otherwise may inhibit erythopoesis
- ECG
- T&S/T&C
- BCx2
- VBG
- UA
- Urine pregnancy
- Head CT/MRI
- If symptoms of stroke
Management
- Analgesia
- IV opiods prefered (Morphine or hydormorphone)
- Avoid IM route (use SQ if necessary)
- Avoid meperidine
- Use PCA pump if available
- Redose in 30min if inadequate
- Normally admit if needs more than three doses
- Use of concurrent acetaminophen encouraged, unless contraindicated
- IV opiods prefered (Morphine or hydormorphone)
- Hydration
- O2 is not useful in the nonhypoxic patient
Anemia
- Transfusion
- Indications:
- Aplastic crisis
- Sequestration crisis
- Hb <6 with inappropriately low retic count
- Hb <10 with acute crisis
- Transfuse 10 mL/kg over 2hr period
- Indications:
Disposition
- Consider admission to the hospital if:
- Acute chest syndrome is suspected
- Sepsis, osteomyelitis, or other serious infection is suspected
- Priapism, aplastic crisis, hypoxia
- WBC >30K
- Plt <100K
- Pain is not under control after 2-3 rounds of analgesics in ED
- <1yr old
- Consider discharge if:
- Pain is under control and patient can take oral fluids and medications
- Ensure appropriate oral analgesics are available
- Provide home care instructions
- Ensure resource for follow-up
See Also
External Links
References
- ↑ Lovett P. et al. Sickle cell disease in the emergency department. Emerg Med Clin North Am. 2014 Aug;32(3):629-47
- ↑ Guy, R. Treatment of Sickle Cell Crisis with Hypotonic Saline Clinical Research 1971; 19: 420
- ↑ Pathogenesis and Treatment of Sickle Cell Disease H. Franklin Bunn, M.D. N Engl J Med 1997; 337:762-769