Ursodiol

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Administration

  • Type: Hepatobiliary
  • Dosage Forms: Cap: 300mg; Tab: 250mg, 500mg
  • Routes of Administration: Oral
  • Common Trade Names: Actigall, Urso 250, Urso Forte

Adult Dosing

Gallstone dissolution

  • 8-10 mg/kg/day PO divided qd-tid

Primary biliary cirrhosis

  • 13-15 mg/kg/day PO divided BID-TID

Primary sclerosing cholangitis

  • 25-30 mg/kg/day PO divided qd-qid

Steatohepatitis, non-alcoholic

  • 10-15 mg/kg/day PO divided qd-qid

Pediatric Dosing

Biliary atresia

  • < 1mo
    • 20-30 mg/kg/day PO divided bid
  • > 1mo
    • 10-30 mg/kg/day PO divided bid

Pruritus, cholestasis-associated

  • > 1mo
    • 15-30 mg/kg/day

Special Populations

Pregnancy Rating

  • May use during pregnancy

Lactation risk

  • May use while breastfeeding

Renal Dosing

  • Adult: Not defined
  • Pediatric: Dose adjustment may be required, but specific guidelines not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Dose adjustment may be required, but specific guidelines not defined

Contraindications

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: Liver, GI tract
  • Excretion: Feces primarily, urine

Mechanism of Action

  • Decreases cholesterol synthesis, secretion, and absorption
  • Alters bile cholesterol composition

Comments

See Also

References

Authors:

Jonathan Warren