Uridine triacetate

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Administration

  • Type: Antidote; Rescue Agent(Chemotherapy)
  • Dosage Forms: Granule 10g
  • Routes of Administration: Oral
  • Common Trade Names: Vistogard

Adult Dosing

Fluorouracil or capecitabine toxicity

  • 10g PO q6h x20 doses
    • Give with soft food

Pediatric Dosing

Fluorouracil or capecitabine toxicity

  • 1+ yr old
  • 6.2 g/m^2 PO q6h x20 doses
    • Give with soft food
    • Max: 10g/dose

Special Populations

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • May occur, but none reported

Common

Pharmacology

  • Half-life: 2-2.5 hrs
  • Metabolism: Tissue, prodrug converted to uridine
  • Excretion: Urine

Mechanism of Action

  • Incorporates into RNA, inhibiting cell damage and death caused by fluoruracil or capecitabine

Comments

See Also

References