Uridine triacetate

Administration

• Type: Antidote; Rescue Agent(Chemotherapy)
• Dosage Forms: Granule 10g
• Routes of Administration: Oral
• Common Trade Names: Vistogard

Adult Dosing

Fluorouracil or capecitabine toxicity

• 10g PO q6h x20 doses
  • Give with soft food

Pediatric Dosing

Fluorouracil or capecitabine toxicity

• 1+ yr old
• 6.2 g/m^2 PO q6h x20 doses
  • Give with soft food
  • Max: 10g/dose

Special Populations

• Pregnancy Rating: C
• Lactation risk: Caution with use, weight risk/benefit

Renal Dosing

• Adult: Not defined
• Pediatric: Not defined

Hepatic Dosing

• Adult: Not defined
• Pediatric: Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• May occur, but none reported

Common

• Vomiting, Nausea
• Diarrhea

Pharmacology

• Half-life: 2-2.5 hrs
• Metabolism: Tissue, prodrug converted to uridine
• Excretion: Urine

Mechanism of Action

• Incorporates into RNA, inhibiting cell damage and death caused by fluoruracil or capecitabine