Unfractionated heparin

Revision as of 06:55, 21 October 2011 by Jswartz (talk | contribs)

Background

  • Binds to and activates antithrombin which in turns inactivates factor Xa and thrombin
  • Half-life is 30-150min
  • Must give IV (not subq) for acute thromboembolic disease
  • Safe in pregnancy
  • Unpredictable anticoagulation effect
    • Must monitor w/ PTT; therapeutic range is 1.5-2.5x normal value

Treatment

  1. See:
    1. DVT
    2. PE
    3. ACS

Source

Tintinalli