Unfractionated heparin

Revision as of 23:17, 17 January 2015 by Rossdonaldson1 (talk | contribs) (Adult Dosing)

General

  • Type:
  • Dosage Forms: IV, SC
  • Common Trade Names:

Adult Dosing

Thromboembolism

  • Bolus: 80 units/kg IV x 1 (MAX: 5,000 units)
  • Then drip: 18 units/kg/h IV (MAX: 1,000 units/h)
  • Adjust dose to target aPTT levels based on nomogram

PCI

  1. See:
    1. DVT
    2. PE
    3. NSTEMI
    4. STEMI

Pediatric Dosing

Special Populations

  • Pregnancy Rating: Safe in pregnancy
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

Risk Factors for Major Bleeding Complication

  1. Recent surgery or trauma
  2. Renal failure
  3. Alcoholism
  4. Malignancy
  5. Liver failure
  6. Concurrent use of warfarin, fibrinolytics, steroids, or antiplatelet drugs

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:


  • Binds to and activates antithrombin which in turns inactivates factor Xa and thrombin
  • Anticoagulation effect lasts up to 3hr after stopping infusion
  • Must give IV (not subq) for acute thromboembolic disease
    • Unpredictable anticoagulation effect
    • Must monitor w/ PTT; therapeutic range is 1.5-2.5x normal value

See Also

Sources