Unfractionated heparin

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Background

Binds to and activates antithrombin which in turns inactivates factor Xa and thrombin
Half-life is 30-150min
Must give IV (not subq) for acute thromboembolic disease
Safe in pregnancy
Unpredictable anticoagulation effect
- Must monitor w/ PTT; therapeutic range is 1.5-2.5x normal value

Treatment

See:
1. DVT
2. PE
3. ACS

Source

Tintinalli

Authors: