Transplant complications: Difference between revisions

No edit summary
No edit summary
Line 22: Line 22:
*Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant <ref>Tintinalli's</ref>
*Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant <ref>Tintinalli's</ref>


<ref name="Tintinalli's">
</references>
<ref name=Tintinalli's>

Revision as of 18:55, 20 June 2015

Background

  • Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)
    • First solid organ transplant was in 1954 (kidney)
  • Most transplant patients require lifelong immunosuppression
  • Types of emergencies
    • transplant-related infection
    • medication side effects
    • rejection
    • graft-versus-host disease
    • postoperative complications and complications of altered physiology secondary to the transplanted organ
  • Often transplant patients present with common medical problems but require unique management due to their altered physiology [1]

Epidemiology

  • Types of presentations
    • Infection (39%)
    • Noninfectious GI/GU pathology (15%)
    • Dehydration (15%)
    • Electrolyte disturbances (10%)
    • Cardiopulmonary pathology (10%)
    • Injury (8%)
    • Rejection (6%)
  • Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant [2]

</references> <ref name=Tintinalli's>

  1. Tintinalli's
  2. Tintinalli's