Transplant complications: Difference between revisions
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==Background== | ==Background== | ||
*Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines) | *Transplanted (solid) organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines) | ||
*Most transplant | *Most transplant-related emergencies due to one of the following: | ||
**Infection | |||
** | **Medication side effect | ||
** | **[[Graft-versus-host disease]] | ||
**Postoperative complications | |||
** | **Altered physiology due to transplanted organ | ||
** | |||
===Epidemiology=== | ===Epidemiology=== | ||
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*Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant <ref>Tintinalli's</ref> | *Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant <ref>Tintinalli's</ref> | ||
{{Immunosuppressant medication complications}} | |||
== | ===Infections<ref>Long B, Koyfman A. The emergency medicine approach to transplant complications. Am J Emerg Med. 2016;34(11):2200-2208.</ref>=== | ||
Time from transplantation affects the risk and type of infection. | |||
*Early (within the first month) | |||
**Donor-derived - bacterial, fungal, parasitic | |||
**Nosocomial & surgical-site - [[C. diff]], [[aspiration Pneumonia]], [[UTI]], surgical-site, superinfection of graft tissue | |||
*Intermediate (1-6 months after) | |||
**'''Highest risk for opportunistic infections''' - [[PCP]], [[TB]], fungal ([[cryptococcus]], [[histoplasma]]), viral (BK virus, [[hepatitis B]]/[[hepatitis C|C]], [[CMV]]) | |||
**Dormant host infection reactivation - [[HSV]], [[VZV]], [[EBV]] | |||
*Late (more than 6 months after) | |||
**Community-acquired infection | |||
== | ==Types== | ||
*[[Graft-vs-host disease]] | |||
*[[Stem cell transplant complications]] | |||
*[[Kidney transplant complications]] | |||
*[[Liver transplant complications]] | |||
*[[Heart transplant complications]] | |||
*[[Lung transplant complications]] | |||
*[[Pancreas transplant complications]] | |||
*More severe or opportunistic infections due to immunocompromise | |||
**May be afebrile due to immunosuppression, have low treshhold for infectious work-up | |||
==See Also== | ==See Also== | ||
*[[Immunocompromised antibiotics]] | |||
==External Links== | ==External Links== | ||
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<references/> | <references/> | ||
[[Category: | [[Category:Surgery]] | ||
[[Category:Misc/General]] | [[Category:Misc/General]] |
Latest revision as of 02:36, 23 August 2019
Background
- Transplanted (solid) organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)
- Most transplant-related emergencies due to one of the following:
- Infection
- Medication side effect
- Graft-versus-host disease
- Postoperative complications
- Altered physiology due to transplanted organ
Epidemiology
- Types of presentations
- Infection (39%)
- Noninfectious GI/GU pathology (15%)
- Dehydration (15%)
- Electrolyte disturbances (10%)
- Cardiopulmonary pathology (10%)
- Injury (8%)
- Rejection (6%)
- Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant [1]
Immunosuppressant Medications
- Balance between immune suppression, rejection and susceptibility to infection
- Typical regimen includes: calcineurin inhibitor + antimetabolite + steroid
- Calcineurin inhibitor
- Steroids
- +/- Antimetabolite
Infections[2]
Time from transplantation affects the risk and type of infection.
- Early (within the first month)
- Donor-derived - bacterial, fungal, parasitic
- Nosocomial & surgical-site - C. diff, aspiration Pneumonia, UTI, surgical-site, superinfection of graft tissue
- Intermediate (1-6 months after)
- Highest risk for opportunistic infections - PCP, TB, fungal (cryptococcus, histoplasma), viral (BK virus, hepatitis B/C, CMV)
- Dormant host infection reactivation - HSV, VZV, EBV
- Late (more than 6 months after)
- Community-acquired infection
Types
- Graft-vs-host disease
- Stem cell transplant complications
- Kidney transplant complications
- Liver transplant complications
- Heart transplant complications
- Lung transplant complications
- Pancreas transplant complications
- More severe or opportunistic infections due to immunocompromise
- May be afebrile due to immunosuppression, have low treshhold for infectious work-up