Difference between revisions of "Torsades de pointes"

(Treatment)
(See Also)
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==See Also==
 
==See Also==
 
*[[Tachycardia (Wide)]]
 
*[[Tachycardia (Wide)]]
*[[ACLS Guidelines (2010)]]
+
*[[ACLS (2010 Guidelines)]]
  
 
==Source ==
 
==Source ==

Revision as of 23:26, 18 July 2011

Background

Drugs that inhibit P450

  1. erythromycin
  2. biaxin
  3. ketoconozole
  4. itraconozole
  • certain antihistamines like terfandadine or astemizole, inhibit the delayed rectifier potassium channel
  • terfenadine is completely metabolized in liver. Once metabolized, has no cardiac activity
  • unmetabolized terfenadine has quinidine- like activity- gives torsades
  • if P450 enz inhibited by other drug, then will have increase in concentration of unmetabolized terfanadine.

Treatment

  1. Mg (1-2gm over 1-2 minutes; then, 1-2gm/hr gtt)
  2. Overdrive pacing (hr = 90-120)
  3. Isoproterenol (if no pacing, 2-8 mcg/min)
  4. lidocaine

See Also

Source

10/07 DONALDSON (adapted from Tintinalli, Lampe)