Difference between revisions of "Torsades de pointes"

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==Background==
 
==Background==
*Most commonly occurs in pts w/ prolonged QT due to heart diseaes or meds:
+
*Form of polymorphic VTach
**Procainamide
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**Gradual change in the amplitude of QRS complexes and twisting around isoelectric line
**Phenothiazine
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*Associated with congenital or acquired [[prolonged QT]]
**TCAs
 
**Qunidine
 
**Disopyramide
 
  
==Treatment==
+
===Common Causes===
#Magnesium
+
'''POINTES''' mnemonic:
##1-2gm IV over 1-2 min; then 1-2gm/hr gtt
+
*'''P'''henothiazines
#Overdrive pacing
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*'''O'''ther medications (ie TCAs)
##Goal HR 90-120
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*'''I'''ntracranial bleed
#Isoproterenol
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*'''N'''o known cause (idiopathic)
##2-8 mcg/min
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*'''T'''ype I anti-arrhythmics (quinidine, procainamide, disopyramide)
 +
*'''E'''lectrolyte abnormalities (hypoK & hypoMag)
 +
*'''S'''yndrome of Prolonged QT (aka Long QT Syndrome)
 +
 
 +
==Clinical Features==
 +
*Syncope
 +
*Dizziness
 +
*Lightheadedness
 +
*Palpitations
 +
*Sudden Cardiac Death
 +
 
 +
==Differential Diagnosis==
 +
*Drug induced
 +
*Congenital long QT
 +
*Hypocalcemia
 +
*Hypomagnesemia
 +
*Hypokalemia
 +
*Hypothermia
 +
*POINTES as above
 +
 
 +
{{Tachycardia (wide) DDX}}
 +
 
 +
==Evaluation==
 +
===Workup===
 +
*[[ECG]]
 +
*BMP, Mg, Phos
 +
 
 +
===Diagnosis===
 +
[[File:12leadTorsade.jpg|thumb|Classic torsades in 12-lead]]
 +
[[File:Torsades de Pointes TdP.png|thumb|Torsades de Pointes (TdP) in patient with a potassium of 2.4 mmol/L and a magnesium of 1.6mg/dL.]]
 +
*[[ECG]] showing the QRS complexes “twisting” around the isoelectric line
 +
 
 +
==Management==
 +
Increasing HR decreases QT interval
 +
#[[Magnesium sulfate]] - decreases calcium influx
 +
#*1-2gm IV over 1-2 min, repeat in 5-15min; then 1-2gm/hr (3-10mg/min) drip
 +
#**Danger of [[hypermagnesemia]] → depressed neuromuscular function and respiratory drive, so monitor closely
 +
#**Supplement with K+
 +
#[[Isoproterenol]] - Increases HR / AV conduction
 +
#*2-8 mcg/min
 +
#*Target HR > 90 bpm
 +
#[[Overdrive Pacing]] - Atrial > Ventricular pacing
 +
#*Goal HR 90-120
 +
#*Note: Not a treatment for TdP, but useful in maintaining sinus rhythm
 +
#[[Defibrillation]] / [[synchronized cardioversion]] - Patient in extremis
 +
#'''AVOID''' amiodarone and procainamide, which may worsen prolonged QT
 +
# Lidocaine (a class Ib antiarrhythmic drug) shortens the QT interval and may be effective especially for drug-induced torsades de pointes.
 +
 
 +
==Disposition==
 +
*Admit
  
 
==See Also==
 
==See Also==
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*[[ACLS (2010 Guidelines)]]
 
*[[ACLS (2010 Guidelines)]]
  
==Source ==
+
==References==
*Tintinalli
+
<references/>
  
[[Category:Cards]]
+
[[Category:Cardiology]]

Revision as of 06:45, 5 April 2019

Background

  • Form of polymorphic VTach
    • Gradual change in the amplitude of QRS complexes and twisting around isoelectric line
  • Associated with congenital or acquired prolonged QT

Common Causes

POINTES mnemonic:

  • Phenothiazines
  • Other medications (ie TCAs)
  • Intracranial bleed
  • No known cause (idiopathic)
  • Type I anti-arrhythmics (quinidine, procainamide, disopyramide)
  • Electrolyte abnormalities (hypoK & hypoMag)
  • Syndrome of Prolonged QT (aka Long QT Syndrome)

Clinical Features

  • Syncope
  • Dizziness
  • Lightheadedness
  • Palpitations
  • Sudden Cardiac Death

Differential Diagnosis

  • Drug induced
  • Congenital long QT
  • Hypocalcemia
  • Hypomagnesemia
  • Hypokalemia
  • Hypothermia
  • POINTES as above

Wide-complex tachycardia

Assume any wide-complex tachycardia is ventricular tachycardia until proven otherwise (it is safer to incorrectly assume a ventricular dysrhythmia than supraventricular tachycardia with abberancy)

^Fixed or rate-related

Evaluation

Workup

  • ECG
  • BMP, Mg, Phos

Diagnosis

Classic torsades in 12-lead
Torsades de Pointes (TdP) in patient with a potassium of 2.4 mmol/L and a magnesium of 1.6mg/dL.
  • ECG showing the QRS complexes “twisting” around the isoelectric line

Management

Increasing HR decreases QT interval

  1. Magnesium sulfate - decreases calcium influx
    • 1-2gm IV over 1-2 min, repeat in 5-15min; then 1-2gm/hr (3-10mg/min) drip
      • Danger of hypermagnesemia → depressed neuromuscular function and respiratory drive, so monitor closely
      • Supplement with K+
  2. Isoproterenol - Increases HR / AV conduction
    • 2-8 mcg/min
    • Target HR > 90 bpm
  3. Overdrive Pacing - Atrial > Ventricular pacing
    • Goal HR 90-120
    • Note: Not a treatment for TdP, but useful in maintaining sinus rhythm
  4. Defibrillation / synchronized cardioversion - Patient in extremis
  5. AVOID amiodarone and procainamide, which may worsen prolonged QT
  6. Lidocaine (a class Ib antiarrhythmic drug) shortens the QT interval and may be effective especially for drug-induced torsades de pointes.

Disposition

  • Admit

See Also

References