Thrombolytics for STEMI
Overview
Indications
Contraindications
Administration
Alteplase (TPA)
Dosing based on patient weight:
- 67kg: Infuse 15mg IV over 1-2min; then 50mg over 30min; then 35mg over next 60min (i.e. 100mg over 1.5hr)
- ≤67kg: Infuse 15mg IV over 1-2min; then 0.75 mg/kg (max 50mg) over 30 min; then 0.5 mg/kg over 60min (max 35 mg)
Tenecteplase (TNKase)
- Reconstitute 50 mg vial in 10 mL sterile water (5 mg/mL)
- < 60 kg = 30 mg IV push over 5 seconds
- 60-69 kg = 35 mg IV push over 5 seconds
- 70-79 kg = 40 mg IV push over 5 seconds
- 80-89 kg = 45 mg IV push over 5 seconds
- > 90 kg = 50 mg IV push over 5 seconds