Thrombocytopenia

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Definition

<150,000 platelets/µL

Transfusion Criteria

<50,000 & severe bleed or invasive procedure

<20,000 & fever, petechia, or infection

<5,000-10,000 --> *always

  • Usually ineffective in ITP (give only in severe bleed; best after IVIg)
  • DIC may worsen with platlet tranfusion
  • Likely contraindicated in TTP


Causes

A. Decreased production

-marrow infiltration, aplastic anemia, drugs (ETOH), viral infect

B. Increased destruction

-ITP, TTP, HUS, DIC, drugs (heparin)

C. Increased loss

-hemorrhage, hemodialysis

D. Splenic sequestration

F. Pseudothrombocytopenia (clumped)


Pediatrics

1 unit platelets per 5kg body weight will raise count by 50k


Source

1/26/06 DONALDSON (addapted from Tintinalli's, Lampe, Charfan)