Thrombocytopenia: Difference between revisions
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*Deep tissue/joint bleeding is less common (more likely due to coagulopathies) | *Deep tissue/joint bleeding is less common (more likely due to coagulopathies) | ||
== | ==Differential Diagnosis== | ||
{{Thrombocytopenia | |||
==Diagnosis== | ==Diagnosis== | ||
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*[[Platelet Transfusion]] | *[[Platelet Transfusion]] | ||
== | ==References== | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Revision as of 05:11, 6 June 2015
Background
- Spontaneous bleeding concerning when platelet count <20K
Clinical Features
- Nonpalpable petechiae/purpura
- Mucosal bleeding (gingival, epistaxis)
- Menorrhagia, hemoptysis, hematuria, hematochezia
- Deep tissue/joint bleeding is less common (more likely due to coagulopathies)
Differential Diagnosis
{{Thrombocytopenia
Diagnosis
- Platelet count (CBC)
Treatment
Platelet Transfusion Thresholds
most if not all of the following thresholds are based on weak recommendations with low quality evidence[1]
- <50K if planned lumbar puncture or neurosurgical procedure[2]
- <20K if planned for central venous catheter placement (preference toward compressible site), or febrile patient
- <10K in asymptomatic patients (unless due to ITP, TTP, or HIT)
There are no firm recommendations for transfusion thresholds in acute traumatic bleeding but many providers will opt for a goal of 100K, especially if there is evidence of ICH
Transfusion contraindications
- TTP, DIC, HIT
Pediatrics
- 1 unit of platelets per 5kg body weight raises count by 50k