View source for Thiopental

==Administration==
*Type: [[Barbiturate]]
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names: 

==Adult Dosing==
*Rapid anesthesia induction: 210 to 280mg (3 to 4 mg/kg) IV divided in 2 to 4 doses
*Anesthesia maintenance: 25-50mg IV repeated PRN '''OR''' continuous IV infusion of 0.2% or 0.4% solution
*Raised ICP: 1.5-3.5 mg/kg IV bolus, repeat PRN
*Seizure: 75-125 mg IV given in single dose
*Seizure due to local anesthetic: 125-250mg IV over 10 min

==Pediatric Dosing==
*Anesthesia induction:
**Neonate: 3 to 4 mg/kg IV
**1mo-1yr: 5 to 8 mg/kg IV
**1-15yo: 5 to 6 mg/kg IV
*Anesthesia maintenance, 1-15yo: 1mg/kg IV repeated PRN

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk minimal
*Renal dosing: for severe impairment, give 75% of usual dose
*Hepatic dosing: 

==Contraindications==
*Allergy to class/drug
*acute intermittent porphyria or variegate porphyria

==Adverse Reactions==
===Serious===
*Respiratory depression, apnea, laryngeal spasm
*Myocardial dysfunction
*Hemolytic anemia
*Raised ICP
*Radial neuropathy
===Common===
*Injection site reaction

==Pharmacology==
*Half-life: 3-18h
*Metabolism: Hepatic
*Excretion: Renal

==Mechanism of Action==
*Ultra-short acting barbiturate, GABA-agonist

==Comments==

==See Also==
*[[Barbiturates]]
*[[Barbiturate toxicity]], [[Barbiturate withdrawal]]

==References==
<references/>
[[Category:Pharmacology]]
[[Category:Critical Care]]