Difference between revisions of "Thiamine"

(Adult Dosing)
 
Line 6: Line 6:
  
 
==Adult Dosing==
 
==Adult Dosing==
*Beriberi
+
*[[Beriberi]]
 
**10-20mg IM tid x 2wk
 
**10-20mg IM tid x 2wk
 
***Then 5-30mg PO QD x1mo
 
***Then 5-30mg PO QD x1mo
Line 13: Line 13:
 
**10-30mg IV tid
 
**10-30mg IV tid
  
*Wernicke's encephalopathy
+
*[[Wernicke-Korsakoff syndrome|Wernicke's encephalopathy]]
 
**High-dose parenteral regimen: 500mg IV TID x 2 days
 
**High-dose parenteral regimen: 500mg IV TID x 2 days
 
***Then 250mg IM/IV QD x 5 days
 
***Then 250mg IM/IV QD x 5 days

Latest revision as of 00:07, 22 October 2020

Administration

  • Dosage Forms: 50,100,250,500mg
  • Routes of Administration: IM, IV
    • Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
  • Common Trade Names: Vitamin B1

Adult Dosing

  • Beriberi
    • 10-20mg IM tid x 2wk
      • Then 5-30mg PO QD x1mo
  • Wet beriberi with CHF
    • 10-30mg IV tid

Pediatric Dosing

Special Populations

Renal Dosing

Not defined

Hepatic Dosing

Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • anaphylaxis
  • angioedema
  • cyanosis

Common

  • injection site pain
  • pruritus
  • warmth sensation
  • urticaria

Pharmacology

  • Half-life: Unknown
  • Metabolism: Liver, CYP450, Unknown
  • Excretion: Urine

Mechanism of Action

Physiologic cofactor

Comments

See Also

Thiamine deficiency types

References