Thiamine

Administration

• Dosage Forms: 50,100,250,500mg
• Routes of Administration: IM, IV
  • Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
• Common Trade Names: Vitamin B1

Adult Dosing

• Beriberi
  • 10-20mg IM tid x 2wk
    • Then 5-30mg PO QD x1mo

• Wet beriberi with CHF
  • 10-30mg IV tid

• Wernicke encephalopathy
  • 100mg IV x1
    • Then 50-100mg IM/IV QD

Special Populations

• Pregnancy Rating: A (according to dietary reference intake)
• Lactation risk: Safe

Renal Dosing

Not defined

Hepatic Dosing

Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• anaphylaxis
• angioedema
• cyanosis

Common

• injection site pain
• pruritus
• warmth sensation
• urticaria

Pharmacology

• Half-life: Unknown
• Metabolism: Liver, CYP450, Unknown
• Excretion: Urine

Mechanism of Action

Physiologic cofactor

See Also

Thiamine deficiency types

• Wernicke-Korsakoff syndrome
• Beriberi

References

• Epocrates: Vitamin B1