Thiamine: Difference between revisions
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*[https://online.epocrates.com/drugs/188810/vitamin-B1-common-name/Monograph Epocrates: Vitamin B1] | *[https://online.epocrates.com/drugs/188810/vitamin-B1-common-name/Monograph Epocrates: Vitamin B1] | ||
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[[Category: | [[Category:Pharmacology]] | ||
Revision as of 15:54, 22 March 2016
Administration
- Dosage Forms: 50,100,250,500mg
- Routes of Administration: IM, IV
- Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
- Common Trade Names: Vitamin B1
Adult Dosing
- Beriberi
- 10-20 mg IM tid x 2wk
- Then 5-30 mg PO qd x1mo
- 10-20 mg IM tid x 2wk
- Wet beriberi w/ CHF
- 10-30 mg IV tid
- Wernicke encephalopathy
- 100 mg IV x1
- Then 50-100 mg IM/IV qd
- 100 mg IV x1
Pediatric Dosing
Special Populations
- Pregnancy Rating: A (according to dietary reference intake)
- Lactation risk: Safe
Renal Dosing
Not defined
Hepatic Dosing
Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- angioedema
- cyanosis
Common
- injection site pain
- pruritus
- warmth sensation
- urticaria
Pharmacology
- Half-life: Unknown
- Metabolism: Liver, CYP450, Unknown
- Excretion: Urine
Mechanism of Action
Physiologic cofactor