Thiamine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*Beriberi | *[[Beriberi]] | ||
**10- | **10-20mg IM tid x 2wk | ||
***Then 5- | ***Then 5-30mg PO QD x1mo | ||
*Wet beriberi | *Wet beriberi with CHF | ||
**10- | **10-30mg IV tid | ||
*Wernicke encephalopathy | *[[Wernicke-Korsakoff syndrome|Wernicke's encephalopathy]] | ||
** | **High-dose parenteral regimen: 500mg IV TID x 2 days | ||
***Then | ***Then 250mg IM/IV QD x 5 days | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
| Line 60: | Line 60: | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:FEN]] | |||
Latest revision as of 00:07, 22 October 2020
Administration
- Dosage Forms: 50,100,250,500mg
- Routes of Administration: IM, IV
- Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
- Common Trade Names: Vitamin B1
Adult Dosing
- Beriberi
- 10-20mg IM tid x 2wk
- Then 5-30mg PO QD x1mo
- 10-20mg IM tid x 2wk
- Wet beriberi with CHF
- 10-30mg IV tid
- Wernicke's encephalopathy
- High-dose parenteral regimen: 500mg IV TID x 2 days
- Then 250mg IM/IV QD x 5 days
- High-dose parenteral regimen: 500mg IV TID x 2 days
Pediatric Dosing
Special Populations
- Pregnancy Rating: A (according to dietary reference intake)
- Lactation risk: Safe
Renal Dosing
Not defined
Hepatic Dosing
Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- angioedema
- cyanosis
Common
- injection site pain
- pruritus
- warmth sensation
- urticaria
Pharmacology
- Half-life: Unknown
- Metabolism: Liver, CYP450, Unknown
- Excretion: Urine
Mechanism of Action
Physiologic cofactor