Thiamine: Difference between revisions

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==Adult Dosing==
==Adult Dosing==
*Beriberi
*Beriberi
**10-20 mg IM tid x 2wk
**10-20mg IM tid x 2wk
***Then 5-30 mg PO qd x1mo
***Then 5-30mg PO QD x1mo


*Wet beriberi w/ CHF
*Wet beriberi with CHF
**10-30 mg IV tid
**10-30mg IV tid


*Wernicke encephalopathy
*Wernicke encephalopathy
**100 mg IV x1
**100mg IV x1
***Then 50-100 mg IM/IV qd
***Then 50-100mg IM/IV QD


==Pediatric Dosing==
==Pediatric Dosing==


==Special Populations==
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: A (according to dietary reference intake)
*[[Lactation risk categories|Lactation risk]]:
*[[Lactation risk categories|Lactation risk]]: Safe
 
===Renal Dosing===
===Renal Dosing===
*Adult:
Not defined
*Pediatric:
===Hepatic Dosing===
===Hepatic Dosing===
*Adult:
Not defined
*Pediatric:


==Contraindications==
==Contraindications==
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==Pharmacology==
==Pharmacology==
*Half-life:  
*Half-life: Unknown
*Metabolism:  
*Metabolism: Liver, CYP450, Unknown
*Excretion:  
*Excretion: Urine


==Mechanism of Action==
==Mechanism of Action==
Physiologic cofactor


==Comments==
==Comments==
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==References==
==References==
*[https://online.epocrates.com/drugs/188810/vitamin-B1-common-name/Monograph Epocrates: Vitamin B1]
<references/>
<references/>
[[Category:Drugs]]
[[Category:Pharmacology]]
[[Category:FEN]]

Revision as of 22:58, 23 September 2019

Administration

  • Dosage Forms: 50,100,250,500mg
  • Routes of Administration: IM, IV
    • Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
  • Common Trade Names: Vitamin B1

Adult Dosing

  • Beriberi
    • 10-20mg IM tid x 2wk
      • Then 5-30mg PO QD x1mo
  • Wet beriberi with CHF
    • 10-30mg IV tid
  • Wernicke encephalopathy
    • 100mg IV x1
      • Then 50-100mg IM/IV QD

Pediatric Dosing

Special Populations

Renal Dosing

Not defined

Hepatic Dosing

Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • anaphylaxis
  • angioedema
  • cyanosis

Common

  • injection site pain
  • pruritus
  • warmth sensation
  • urticaria

Pharmacology

  • Half-life: Unknown
  • Metabolism: Liver, CYP450, Unknown
  • Excretion: Urine

Mechanism of Action

Physiologic cofactor

Comments

See Also

Thiamine deficiency types

References