Difference between revisions of "Tetrodotoxin"

(Management)
(Background)
Line 1: Line 1:
 
==Background==
 
==Background==
 
*Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)
 
*Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)
 +
**Heat-stable toxin not destroyed by washing, freezing or cooking
 
*Blocks neuronal action potential by blocking voltage-gated sodium channels
 
*Blocks neuronal action potential by blocking voltage-gated sodium channels
 
*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity
 
*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity

Revision as of 16:56, 11 September 2017

Background

  • Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)
    • Heat-stable toxin not destroyed by washing, freezing or cooking
  • Blocks neuronal action potential by blocking voltage-gated sodium channels
  • Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity

Clinical Features

Onset of symptoms usually within 30 min to 4 hours after eating pufferfish

Differential Diagnosis

Marine toxins, envenomations, and bites

Evaluation

  • Pufferfish can be tested for the toxin, but decision to treat should be based on clinical picture
  • Evaluate for other treatable causes of symptoms

Management

Disposition

  • Admit, may need ICU

See Also

External Links

References

  1. Tintanelli's