Difference between revisions of "Tetrodotoxin"

(Created page with "==Background== *Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus) *Blocks neuronal action potential by blocking voltage-gated sod...")
 
(Clinical Features)
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*Ascending paralysis
 
*Ascending paralysis
 
*Respiratory failure
 
*Respiratory failure
**Death
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*Death
  
 
==Differential Diagnosis==
 
==Differential Diagnosis==

Revision as of 01:47, 6 September 2016

Background

  • Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)
  • Blocks neuronal action potential by blocking voltage-gated sodium channels
  • Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity

Clinical Features

Onset of symptoms usually within 30 min to 4 hours after eating pufferfish

Differential Diagnosis

Evaluation

  • Pufferfish can be tested for the toxin, but decision to treat should be based on clinical picture
  • Evaluate for other treatable causes of symptoms

Management

  • Supportive care, intubate if concern for progressive paralysis
  • Acetylcholinesterase inhibitors (e.g. neostigmine)[1]

Disposition

  • Admit, may need ICU

See Also

External Links

References

  1. Tintanelli's