Difference between revisions of "Tetrodotoxin"

(added video summarizing tetrodotoxin)
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**Heat-stable toxin not destroyed by washing, freezing or cooking
 
**Heat-stable toxin not destroyed by washing, freezing or cooking
 
*Blocks neuronal action potential by blocking voltage-gated sodium channels
 
*Blocks neuronal action potential by blocking voltage-gated sodium channels
*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity
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*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity (e.g. fugu restaurants)
 
[[File:Blue-ringed-octopus.jpeg|thumbnail]]
 
[[File:Blue-ringed-octopus.jpeg|thumbnail]]
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 +
==Mechanism of Injury==
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*Tetrodotoxin binds to and blocks fast-gated sodium channels, blocking conduction of nerve signals.
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==Clinical Features==
 
==Clinical Features==
 
''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''
 
''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''
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==Disposition==
 
==Disposition==
 
*Admit, may need ICU
 
*Admit, may need ICU
 +
 
==See Also==
 
==See Also==
 
*[[Marine toxins and envenomations]]
 
*[[Marine toxins and envenomations]]
==External Links==
 
  
 
==References==
 
==References==
 
<references/>
 
<references/>
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==Video==
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{{#widget:YouTube|id=0DyrwwGQnlI}}
  
 
[[Category:Toxicology]]
 
[[Category:Toxicology]]

Revision as of 16:14, 4 March 2019

Background

  • Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)
    • Heat-stable toxin not destroyed by washing, freezing or cooking
  • Blocks neuronal action potential by blocking voltage-gated sodium channels
  • Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity (e.g. fugu restaurants)
Blue-ringed-octopus.jpeg

Mechanism of Injury

  • Tetrodotoxin binds to and blocks fast-gated sodium channels, blocking conduction of nerve signals.

Clinical Features

Onset of symptoms usually within 30 min to 4 hours after eating pufferfish

Differential Diagnosis

Marine toxins, envenomations, and bites

Evaluation

  • Pufferfish can be tested for the toxin, but decision to treat should be based on clinical picture
  • Evaluate for other treatable causes of symptoms

Management

Disposition

  • Admit, may need ICU

See Also

References

  1. Tintanelli's

Video