Template:Thrombocytopenia: Difference between revisions

Latest revision as of 14:52, 1 September 2019

Thrombocytopenia

Decreased production

Marrow infiltration (tumor or infection)
Viral infections (rubella, HIV)
Marrow suppression (commonly chemotherapy or radiation)
Congenital thrombocytopenia
- Fanconi anemia
- Alport syndrome
- Bernand Soulier
Vitamin B12 and/or folate deficiency

Increased platelet destruction or use

Idiopathic thrombocytopenic purpura
Thrombotic Thrombocytopenic Purpura (TTP)
Hemolytic Uremic Syndrome (HUS)
Disseminated Intravascular Coagulation (DIC)
Viral infections (HIV, mumps, varicella, EBV)
Drugs (heparin, protamine)
Postransfusion or Posttransplantation
Autoimmune destruction (SLE or Sarcoidosis)
Mechanical destruction
- Artificial valves
- ECMO
HELLP syndrome
Excessive hemorrhage
Hemodialysis, extracorporeal circulation
Splenic Sequestration
- Occurs in Sickle cell disease and Cirrhosis

Drug Induced

sulfa antibiotics, ETOH, ASA, thiazide diuretics/furosemide

Comparison by Etiology

	ITP	TTP	HUS	HIT	DIC
↓ PLT	Yes	Yes	Yes	Yes	Yes
↑PT/INR	No	No	No	+/-	Yes
MAHA	No	Yes	Yes	No	Yes
↓ Fibrinogen	No	No	No	No	Yes
Ok to give PLT	Yes	No	No	No	Yes

@@ Line 1: / Line 1: @@
 ===[[Thrombocytopenia]]===
-*Decreased production
+====Decreased production====
-**Marrow infiltration (tumor or infection)
+*Marrow infiltration (tumor or infection)
-**Viral infections (rubella, HIV)
+*Viral infections ([[rubella]], [[HIV]])
-**Drugs
+*Marrow suppression (commonly chemotherapy or radiation)
-***[[Heparin Induced Thrombocytopenia]]
+*Congenital thrombocytopenia
-***sulfa antibiotics, ETOH, ASA, thiazides/furosemide
+**Fanconi anemia
-**Radiation
+**[[Alport syndrome]]
-**Vitamin B12 and/or folate deficiency
+**Bernand Soulier
-*Increased platelet destruction
+*[[Vitamin B12 deficiency|Vitamin B12]] and/or [[folate deficiency]]
-**[[Idiopathic thrombocytopenic purpura]]
+====Increased platelet destruction or use====
-**[[TTP]]
+*[[Idiopathic thrombocytopenic purpura]]
-**[[HUS]]
+*[[Thrombotic Thrombocytopenic Purpura (TTP)]]
-**[[DIC]]
+*[[Hemolytic Uremic Syndrome (HUS)]]
-**Viral infections (HIV, mumps, varicella, EBV)
+*[[Disseminated Intravascular Coagulation (DIC)]]
-**Drugs (heparin, protamine)
+*Viral infections ([[HIV]], [[mumps]], [[varicella]], [[EBV]])
-*Platelet loss
+*Drugs ([[heparin]], [[protamine]])
-**Excessive hemorrhage
+*Postransfusion or Posttransplantation
-**Hemodialysis, extracorporeal circulation
+*Autoimmune destruction ([[SLE]] or [[Sarcoidosis]])
-*Splenic sequestration
+*Mechanical destruction
-**Sickle cell disease, cirrhosis
+**Artificial valves
+**[[ECMO]]
+*[[HELLP]] syndrome
+*Excessive [[hemorrhage]]
+*[[Hemodialysis]], extracorporeal circulation
+*Splenic Sequestration
+**Occurs in [[Sickle cell disease]] and [[Cirrhosis]]
+====Drug Induced====
+*sulfa antibiotics, [[ETOH]], [[ASA]], thiazide [[diuretics]]/[[furosemide]]
+====Comparison by Etiology====
+{|  class="wikitable"  style="text-align:center"
+!
+! [[Immune thrombocytopenic purpura|ITP]]
+! [[Thrombotic thrombocytopenic purpura|TTP]]
+! [[Hemolytic uremic syndrome|HUS]]
+! [[Heparin-Induced Thrombocytopenia (HIT)|HIT]]
+! [[Disseminated intravascular coagulation|DIC]]
+|-
+! ↓ PLT
+|Yes||Yes||Yes||Yes||Yes
+|-
+! ↑PT/INR
+||No||No||No||+/-||Yes
+|-
+![[Microangiopathic hemolytic anemia|MAHA]]
+||No||Yes||Yes||No||Yes
+|-
+!↓ Fibrinogen
+||No||No||No||No||Yes
+|-
+!Ok to give PLT
+||Yes||No||No||No||Yes
+|-
+|}