Template:Antibiotics Open Fracture

Prophylactic Antibiotics for Open fractures[1]

Initiate as soon as possible; increased infection rate when delayed for >3 hours from injury (NNT 12.5)[2]

Grade I & II Fractures Options

Grade III Fracture Options

  • Treatment as above for Grade I/II
  • PLUS aminoglycoside: e.g. Gentamicin 300 mg (1-1.7mg/kg) IV
    • Once daily dosing has been shown to be safe and effective

Special Considerations

  • Open Fractures, Prophylactic Antibiotic Use in — Update. https://www.east.org/education/practice-management-guidelines/open-fractures-prophylactic-antibiotic-use-in-update
  • Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.