Synthetic cannabinoids

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Background

  • Common names: spice, K2, Moon Rocks, Blue Lotus, many others
  • Active ingredients: cannabicyclohexano, JWH-018, JWH-073, HU-210, others
  • Far more potent than THC (100-800x)
  • Cannabinoid receptor agonists (CB1 or CB2)
  • Do not show up as marijuana on routine tox testing
  • Generally smoked, but can be drank as a tea

Clinical Features

  • Similar effect to marijuana at low doses, but may be more intense and cause an acute agitated delerium
  • Typical effects 10-30 min and taper over 1-2 hours
  • Tachycardia and hypertension common (distinguishing it from MJ use)
  • Adverse effects: nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli

Treatment

  • Supportive 
  • Benzodiazepines
  • Zofran



Source

David Burbulys, MD lecture 9/2012