Succimer

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Administration

  • Type: Antidote
  • Dosage Forms: Capsule 100mg
  • Routes of Administration: Oral
  • Common Trade Names: Chemet

Adult Dosing

Lead poisoning

  • 10 to 30 mg/kg/day for 5 days

Pediatric Dosing

Safety/efficacy not established in patients <12mo

  • Lead poisoning, level >45 mcg/dL: 10 mg/kg or 350 mg/m(2) q8h for 5 days, then q12 h for 14 days

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Avoid breastfeeding during treatment and for at least 5 days after d/c. Possible risk of infant toxicity
  • Renal dosing: administer with caution, ensure adequate hydration
  • Hepatic dosing: no adjustment, monitor LFTs closely

Contraindications

  • Allergy to class/drug
  • Breastfeeding during treatment and five days after d/c
  • ANC < 1200

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 48h
  • Metabolism: Site unknown
  • Excretion: Renal 25%, feces 39%, lungs 1%

Mechanism of Action

  • Forms stable, water-soluble complexes with lead, leading to increased urinary excretion

Comments

See Also

References