Difference between revisions of "Stevens-Johnson syndrome and toxic epidermal necrolysis"

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==Background==
 
==Background==
*SJS and TEN involve IC-mediated cell death w/ separation of epidermis from dermis
+
*SJS and TEN involve immune-complex mediated cell death w/ separation of epidermis from dermis
 
**SJS involves <10% of BSA
 
**SJS involves <10% of BSA
 
**TEN involves >30% of BSA
 
**TEN involves >30% of BSA

Revision as of 00:42, 18 February 2012

Background

  • SJS and TEN involve immune-complex mediated cell death w/ separation of epidermis from dermis
    • SJS involves <10% of BSA
    • TEN involves >30% of BSA

Diagnosis

  • Often have prodrome (fever, URI symptoms, HA, malaise)
  • Rash begins suddenly
    • Target lesions
  • Mucous membranes can be severely affected
    • Eye involvement can be severe
  • In severe cases, respiratory tract and GI involvement may occur

Work-Up

  • CBC
  • Chem
  • ESR
  • CXR

Treatment

  • Removal of inciting cause if identified
  • Treat shock w/ IV fluids according to burn protocols

Disposition

  • Admit to burn unit or ICU

Source

Tintinalli