Difference between revisions of "Stevens-Johnson syndrome and toxic epidermal necrolysis"

(Created page with "==Background== *SJS and TEN involve IC-mediated cell death w/ separation of epidermis from dermis **SJS involves <10% of BSA **TEN involves >30% of BSA ==Diagnosis== *Often have...")
 
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==Diagnosis==
 
==Diagnosis==
 
*Often have prodrome (fever, URI symptoms, HA, malaise)
 
*Often have prodrome (fever, URI symptoms, HA, malaise)
*Rash begins suddenly, mucus membranes are severely affected
+
*Rash begins suddenly
**Target lesion
+
**Target lesions
 +
*Mucous membranes can be severely affected
 
**Eye involvement can be severe
 
**Eye involvement can be severe
**In severe cases, respiratory tract and GI involvement may occur
+
*In severe cases, respiratory tract and GI involvement may occur
  
 
==Work-Up==
 
==Work-Up==

Revision as of 19:39, 2 February 2012

Background

  • SJS and TEN involve IC-mediated cell death w/ separation of epidermis from dermis
    • SJS involves <10% of BSA
    • TEN involves >30% of BSA

Diagnosis

  • Often have prodrome (fever, URI symptoms, HA, malaise)
  • Rash begins suddenly
    • Target lesions
  • Mucous membranes can be severely affected
    • Eye involvement can be severe
  • In severe cases, respiratory tract and GI involvement may occur

Work-Up

Treatment

  • Removal of inciting cause if identified
  • Treat shock w/ IV fluids according to burn protocols

Disposition

  • Admit to burn unit or ICU

Source

Tintinalli