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Administration
- Type:
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names: Ammunol
Adult Dosing
Pediatric Dosing
- <20kg: 250mg/kg in D10 over 90min; then 250mg/kg/d infusion
- >20kg: 5.5g/m2 over 90-120min
Special Populations
Lactation risk
Renal Dosing
- Adult: Monitor closely
- Pediatric: Monitor closely
Hepatic Dosing
- Adult: caution with use
- Pediatric: caution with use
Contraindications
Adverse Reactions
Serious
- Hypokalemia
- Fluid overload
- Tissue damage with extravasation from peripheral IV
- Neurotoxicity, seizure, coma
- Hyperventilation with metabolic acidosis (similar to salicylate toxicity)
Common
- Vomiting, hyperglycemia, hypokalemia, convulsions, and mental impairment.
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
See Also
References