Sarcoidosis: Difference between revisions

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**[[Pneumothorax]]
**[[Pneumothorax]]
*[[Erythema nodosum]] and other skin lesions
*[[Erythema nodosum]] and other skin lesions
**[[Lupus pernio]] is pathognomonic for sarcoidosis and the most specific physical exam finding<ref>James WD, Berger TG, Elston DM. Macrophage/Monocyte Disorders. In: James WD, Berger TG, Elston DM (eds). Andrews’ Diseases of the Skin, 12e. Philadelphia, PA: Elsevier; 2016, Chapter 31.</ref>
*Fatigue
*Fatigue
*Weight loss
*Weight loss
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**[[Optic neuritis]]
**[[Optic neuritis]]
**[[Iritis]]
**[[Iritis]]


==Differential Diagnosis==
==Differential Diagnosis==

Revision as of 20:24, 1 February 2021

Background

  • Abnormal collection of inflammatory cells (granulomas) throughout the body.
    • Most common location for granulomas to occur are the lung, skin, heart, and brain.
    • Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
    • Do not confuse with infectious granulomatous processes such as tuberculosis.

Clinical Features

Sarcoidosis. (A) Subcutaneous nodules without changes in overlying epidermis. (B) Characteristic non-caseating granuloma with giant cell.

Depend on location of granulomata. May be entirely asymptomatic.

Differential Diagnosis

Evaluation

Sarcoid Xray - hilar adenopathy
  • Definitive initial diagnosis unlikely to be made in ED, but may be suggested by typical granulomatous lesions seen on CT or other imaging in setting of appropriate clinical context
  • Evaluate for complications/alternative diagnoses of presenting symptoms

Management

Disposition

  • Dependent on presentation

See Also

External Links

References

  1. James WD, Berger TG, Elston DM. Macrophage/Monocyte Disorders. In: James WD, Berger TG, Elston DM (eds). Andrews’ Diseases of the Skin, 12e. Philadelphia, PA: Elsevier; 2016, Chapter 31.