Salmeterol

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Administration

  • Type: Beta-2 agonist, bronchodilator
  • Dosage Forms:
  • Routes of Administration: Inhalation
  • Common Trade Names:

Adult Dosing

  • 1 oral inhalation (50mcg) q12h

Pediatric Dosing

  • >4yo: 1 oral inhalation (50mcg) q12h

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Severe asthma exacerbation, asthma-related death
  • Prolonged QT interval

Common

  • Musculoskeletal pain
  • Headache

Pharmacology

  • Half-life: 5.5h
  • Metabolism: Hepatic
  • Excretion: Mostly fecal

Mechanism of Action

  • Long-acting beta-2 agonist, stimulates adenyl cyclase→ increased levels of cyclic AMP→ bronchial smooth muscle relaxation

Comments

See Also

References