SSRI toxicity

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  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes


  • GI decontamination
    • Activated charcoal x1
    • Gastric lavage unnecessary


  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion

See Also


  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.