SSRI toxicity

Revision as of 14:23, 1 September 2019 by Beren85 (talk | contribs) (Disposition)


  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes


  • Supportive care
  • No role for activated charcoal or gastric lavage
  • Magnesium sulfate 2g IV if QTc > 500 msec
  • IV benzodiazepines if agitation or seizures


  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion
  • ECG before clearing a patient with citalopram ingestion

See Also


  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.