Rocuronium
See critical care quick reference for drug doses by weight.
General
- Type: Neuromuscular blocker, Non-Depolarizing, Fast Onset, Intermediate Lasting
- Dosage Forms: IV
- Common Trade Names: Zemuron
Adult Dosing
RSI
- 0.6 to 1.2mg/kg IV (actual body weight)
Maintenance Bolus Dosing
- 0.1 to 0.2mg/kg IV
Infusion
- 10 to 12 mcg/kg/min
Pediatric Dosing
See critical care quick reference for drug doses by weight.
RSI
- 0.6 to 1.2mg/kg IV (actual body weight)
Maintenance Bolus Dosing
- 0.1 to 0.2mg/kg IV
Infusion
- 10 to 12 mcg/kg/min
Special Populations
- Pregnancy Rating: C
- Lactation: Infant risk cannot be ruled out
- Renal Dosing (half life approximately 1 hour longer if renal transplant patient)
- Adult
- Pediatric
- Hepatic Dosing (half life approximately 3 hours longer with liver dysfunction)
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
- Cardiovascular: hypertension (0.1% to 2%)
- Hypotension (0.1% to 2%)
- Tachycardia (1% to 5.3%)
- Dermatologic: Pain at injection site
- Respiratory: Increased pulmonary vascular resistance (24%)
Pharmacology
- Half-life: Variable by age, but anywhere from 30 minutes to 2 hours.
- Metabolism: Metabolite is 17-desacetyl-rocuronium
- Excretion: Primary route is fecal. Renal also.
- Mechanism of Action: Non-depolarizing neuromuscular blocking agent. Intermediate duration with dose dependant rapid to intermediate onset. Competes for cholinergic receptors at the motor end-plate. Acetylcholinesterase inhibitors like those found in organophosphates antagonize this action
See Also
- Critical care quick reference
- Reversal agent: Sugammadex