Ritonavir: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: | *Type: [[Antiviral]] | ||
*Dosage Forms: | *Dosage Forms: 100 mg | ||
*Routes of Administration: | *Routes of Administration: PO | ||
*Common Trade Names: | *Common Trade Names: Norvir | ||
==Adult Dosing== | ==Adult Dosing== | ||
*HIV Treatment | |||
*HIV post-exposure prophylaxis | |||
* | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*HIV Treatment | |||
*HIV post-exposure prophylaxis | |||
* | |||
==Special Populations== | ==Special Populations== | ||
===[[Drug pregnancy categories|Pregnancy Rating]]=== | ===[[Drug pregnancy categories|Pregnancy Rating]]=== | ||
* | *HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content. | ||
===Lactation risk=== | ===Lactation risk=== | ||
* | *Avoid breastfeeding | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: | *Adult: No adjustment | ||
*Pediatric: | *Pediatric: Not defined, but likely no adjustment as in adults | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
*Adult: | *Adult: | ||
**Mild-moderate impairment: no adjustment | |||
**Severe impairment: not defined | |||
*Pediatric: | *Pediatric: | ||
**Mild-moderate impairment: no adjustment | |||
**Severe impairment: not defined | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Hepatotoxicity | |||
*[[Pancreatitis]] | |||
*GI bleed | |||
*Hypersensitivity reaction | |||
*[[Anaphylaxis]] | |||
*[[Toxic epidermal necrolysis]] | |||
*[[Stevens-Johnson syndrome]] | |||
*PR prolongation/AV block | |||
*Hypercholesterolemia/hypertriglyceridemia | |||
*[[Diabetes mellitus]]/hyperglycemia | |||
*[[Immune reconstitution syndrome]] | |||
*Autoimmune disorders | |||
*[[Hypertension]] | |||
*[[Syncope]] | |||
*Orthostatic hypotension | |||
*Myopathy | |||
*[[Thrombocytopenia]] | |||
===Common=== | ===Common=== | ||
*Nausea/vomiting | |||
*Diarrhea | |||
*Paresthesia | |||
*Fatigue | |||
*Rash | |||
*Abdominal pain | |||
*Cough | |||
*Dysgeusia | |||
*Oropharyngeal pain | |||
*Dizziness | |||
*AST, ALT, CK elevation | |||
*Edema | |||
*Acne | |||
*Lipodystrophy | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 3-5 hours | ||
*Metabolism: | *Metabolism: Liver (CYP450) | ||
*Excretion: | *Excretion: Fecal | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Revision as of 12:27, 22 March 2020
Administration
- Type: Antiviral
- Dosage Forms: 100 mg
- Routes of Administration: PO
- Common Trade Names: Norvir
Adult Dosing
- HIV Treatment
- HIV post-exposure prophylaxis
Pediatric Dosing
- HIV Treatment
- HIV post-exposure prophylaxis
Special Populations
Pregnancy Rating
- HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content.
Lactation risk
- Avoid breastfeeding
Renal Dosing
- Adult: No adjustment
- Pediatric: Not defined, but likely no adjustment as in adults
Hepatic Dosing
- Adult:
- Mild-moderate impairment: no adjustment
- Severe impairment: not defined
- Pediatric:
- Mild-moderate impairment: no adjustment
- Severe impairment: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hepatotoxicity
- Pancreatitis
- GI bleed
- Hypersensitivity reaction
- Anaphylaxis
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
- PR prolongation/AV block
- Hypercholesterolemia/hypertriglyceridemia
- Diabetes mellitus/hyperglycemia
- Immune reconstitution syndrome
- Autoimmune disorders
- Hypertension
- Syncope
- Orthostatic hypotension
- Myopathy
- Thrombocytopenia
Common
- Nausea/vomiting
- Diarrhea
- Paresthesia
- Fatigue
- Rash
- Abdominal pain
- Cough
- Dysgeusia
- Oropharyngeal pain
- Dizziness
- AST, ALT, CK elevation
- Edema
- Acne
- Lipodystrophy
Pharmacology
- Half-life: 3-5 hours
- Metabolism: Liver (CYP450)
- Excretion: Fecal