Difference between revisions of "Ritonavir"

(Created page with "==Administration== *Type: *Dosage Forms: *Routes of Administration: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Special Populations== ===Drug pregnan...")
 
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==Administration==
 
==Administration==
*Type:  
+
*Type: [[Antiviral]]
*Dosage Forms:
+
*Dosage Forms: 100 mg
*Routes of Administration:
+
*Routes of Administration: PO
*Common Trade Names:  
+
*Common Trade Names: Norvir
  
 
==Adult Dosing==
 
==Adult Dosing==
 
+
*HIV Treatment
 +
*HIV post-exposure prophylaxis
 +
*
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
 
+
*HIV Treatment
 +
*HIV post-exposure prophylaxis
 +
*
  
 
==Special Populations==
 
==Special Populations==
 
===[[Drug pregnancy categories|Pregnancy Rating]]===
 
===[[Drug pregnancy categories|Pregnancy Rating]]===
*
+
*HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content.
  
 
===Lactation risk===
 
===Lactation risk===
*
+
*Avoid breastfeeding
  
 
===Renal Dosing===
 
===Renal Dosing===
*Adult:
+
*Adult: No adjustment
*Pediatric:
+
*Pediatric: Not defined, but likely no adjustment as in adults
  
 
===Hepatic Dosing===
 
===Hepatic Dosing===
 
*Adult:
 
*Adult:
 +
**Mild-moderate impairment: no adjustment
 +
**Severe impairment: not defined
 
*Pediatric:
 
*Pediatric:
 
+
**Mild-moderate impairment: no adjustment
 +
**Severe impairment: not defined
 
==Contraindications==
 
==Contraindications==
 
*Allergy to class/drug
 
*Allergy to class/drug
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==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
 
+
*Hepatotoxicity
 +
*[[Pancreatitis]]
 +
*GI bleed
 +
*Hypersensitivity reaction
 +
*[[Anaphylaxis]]
 +
*[[Toxic epidermal necrolysis]]
 +
*[[Stevens-Johnson syndrome]]
 +
*PR prolongation/AV block
 +
*Hypercholesterolemia/hypertriglyceridemia
 +
*[[Diabetes mellitus]]/hyperglycemia
 +
*[[Immune reconstitution syndrome]]
 +
*Autoimmune disorders
 +
*[[Hypertension]]
 +
*[[Syncope]]
 +
*Orthostatic hypotension
 +
*Myopathy
 +
*[[Thrombocytopenia]]
  
 
===Common===
 
===Common===
 
+
*Nausea/vomiting
 +
*Diarrhea
 +
*Paresthesia
 +
*Fatigue
 +
*Rash
 +
*Abdominal pain
 +
*Cough
 +
*Dysgeusia
 +
*Oropharyngeal pain
 +
*Dizziness
 +
*AST, ALT, CK elevation
 +
*Edema
 +
*Acne
 +
*Lipodystrophy
  
 
==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 3-5 hours
*Metabolism:  
+
*Metabolism: Liver (CYP450)
*Excretion:  
+
*Excretion: Fecal
  
 
==Mechanism of Action==
 
==Mechanism of Action==

Revision as of 12:27, 22 March 2020

Administration

  • Type: Antiviral
  • Dosage Forms: 100 mg
  • Routes of Administration: PO
  • Common Trade Names: Norvir

Adult Dosing

  • HIV Treatment
  • HIV post-exposure prophylaxis

Pediatric Dosing

  • HIV Treatment
  • HIV post-exposure prophylaxis

Special Populations

Pregnancy Rating

  • HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content.

Lactation risk

  • Avoid breastfeeding

Renal Dosing

  • Adult: No adjustment
  • Pediatric: Not defined, but likely no adjustment as in adults

Hepatic Dosing

  • Adult:
    • Mild-moderate impairment: no adjustment
    • Severe impairment: not defined
  • Pediatric:
    • Mild-moderate impairment: no adjustment
    • Severe impairment: not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

  • Nausea/vomiting
  • Diarrhea
  • Paresthesia
  • Fatigue
  • Rash
  • Abdominal pain
  • Cough
  • Dysgeusia
  • Oropharyngeal pain
  • Dizziness
  • AST, ALT, CK elevation
  • Edema
  • Acne
  • Lipodystrophy

Pharmacology

  • Half-life: 3-5 hours
  • Metabolism: Liver (CYP450)
  • Excretion: Fecal

Mechanism of Action

Comments

See Also

References